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While at the Francis Crick Institute (2021–)#

Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference
Jamal El Bakali, Michal Blaszczyk, Joanna C Evans, Jennifer A Boland, William J McCarthy, Imam Fathoni, Marcio V B Dias, Eachan O Johnson, Anthony G Coyne, Valerie Mizrahi, Tom L Blundell, Chris Abell, Christina Spry
Frontiers in Cellular and Infection Microbiology, Oct 2022, 12: 954074
PubMed ID: 36757665

Evolution of Mycobacterium tuberculosis drug resistance in the genomic era
Nimmo C, Millard J, Faulkner V, Monteserin J, Pugh H, Johnson EO
Frontiers in Cellular and Infection Microbiology, Oct 2022, 12: 954074
PubMed ID: 36275027


While at the Broad Institute (2014-2020)#

Using Proteolytic Hypomorphs to Detect Small Molecule Mechanism of Action
Johnson EO, Hung DT
Methods in Molecular Biology, Jun 2021, 2314, 323–342
PubMed ID: 34235661

PROSPECT overview

Large-scale chemical-genetic strategy enables the design antimicrobial combination chemotherapy in Mycobacteria
Johnson EO, Office E, Kawate T, Orzechowski M, Hung DT
ACS Infectious Diseases, Jan 2020, 6(1), 56–63
PubMed ID: 31721551

BRD-8000.3 and BRD-9327 EfpA

A point of inflection and reflection on systems chemical biology
Johnson EO, Hung DT
ACS Chemical Biology, Dec 2019, 14(12), 2497–2511
PubMed ID: 3161359

Systems chemical biology

Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes
Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez J, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, Golas A, Guinn KM, Kennedy S, Korn R, McConnell JA, Moss CE, Murphy KC, Nietupski R, Papavinasasundaram KG, Pinkham JT, Pino PA, Proulx MK, Ruecker N, Song N, Thompson M, Trujillo C, Wakabayashi S, Wallach JB, Watson C, Ioerger TR, Lander ES, Hubbard BK, Serrano-Wu MH, Ehrt S, Fitzgerald M, Rubin EJ, Sassetti CM, Schnappinger D, Hung DT
Nature, Jul 2019, 571, 72-78
PubMed ID: 31217586

  • Covered in C&E News: Speeding tuberculosis drug development

  • Highlighted in Nature Reviews Drug Discovery, Nature Chemical Biology, and Biochemistry


While at University of Oxford (2009-2013)#

A structural model of a P450-ferredoxin complex from orientation-selective double electron-electron resonance spectroscopy
Bowen AM, Johnson EO, Mercuri F, Hoskins NJ, Qiao R, McCullagh JSO, Lovett JE, Bell SG, Zhou W, Timmel CR, Wong LL, Harmer JR
Journal of the American Chemical Society, Feb 2018, 140(7), 2514-2527
PubMed ID: 29266939

Partial fusion of a cytochrome P450 system by carboxy-terminal attachment of putidaredoxin reductase to P450cam (CYP101A1)
Johnson EO, Wong LL
Catalysis Science and Technology, Sep 2016, 6(20), 7549-7560
PubMed ID: 28944003

Tailoring an alien ferredoxin to support native-like P450 monooxygenase activity
Bell SG, McMillan JH, Yorke JA, Kavanagh E, Johnson EO, Wong LL
Chemical Communications, Dec 2012, 48(95), 11692-11694
PubMed ID: 23104016

Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation
Boehringer J, Riedinger C, Paraskevopoulos K, Johnson EO, Lowe ED, Khoudian C, Smith D, Noble ME, Gordon C, Endicott JA
Biochemical Journal, Nov 2012, 448(1), 55-65
PubMed ID: 22906049

The crystal structures of 4-methoxybenzoate bound CYP199A2 and CYP199A4: structural changes on substrate binding and the identification of an anion binding site
Bell SG, Yang W, Tan AB, Zhou R, Johnson EO, Zhang A, Zhou W, Rao Z, Wong LL
Dalton Transactions, Jul 2012, 41(28), 8703-8714
PubMed ID: 22695988

Selective oxidative demethylation of veratric acid to vanillic acid by CYP199A4 from Rhodopseudomonas palustris HaA2
Bell SG, Tan AB, Johnson EO, Wong LL
Molecular BioSystems, Jan 2010, 6(1), 206-214
PubMed ID: 20024082

Protein recognition in ferredoxin-P450 electron transfer in the class I CYP199A2 system from Rhodopseudomonas palustris
Bell SG, Xu F, Johnson EO, Forward IM, Bartlam M, Rao Z, Wong LL
Journal of Biological Inorganic Chemistry, Mar 2010, 15(3), 315-28
PubMed ID: 19904564

Crystal structure of a ferredoxin reductase for the CYP199A2 system from Rhodopseudomonas palustris
Xu F, Bell SG, Peng Y, Johnson EO, Bartlam M, Rao Z, Wong LL
Proteins, Dec 2009, 77(4), 867-880
PubMed ID: 19626710